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Numerical simulation and stability study of skin drug delivery via polymeric microneedles | ||
| Computational Methods for Differential Equations | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 13 تیر 1405 اصل مقاله (2.29 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/cmde.2026.58857.2494 | ||
| نویسندگان | ||
| Ebrahim Azhdari* ؛ Aram Emami | ||
| Department of Mathematics and Computer Science, Faculty of Basic Sciences, Salman Farsi University of Kazerun, Kazerun, Iran. | ||
| چکیده | ||
| Drug delivery through reservoir-based microneedle has become highly important owing to its non-invasiveness and the ability to deliver a wide range of drugs. In this paper, we consider a system of partial differential equations to describe the transport of bounded drug, free drug and water in the reservoir, microneedle, skin and blood vessel. The system of equations is completed with interface boundary conditions, initial and boundary conditions. Additionally, the initial and boundary value problem is studied from an analytical point of view for stability, and from a numerical point of view for qualitative behaviour. Finally, it is shown that the results agree well with the experimental data. | ||
| کلیدواژه‌ها | ||
| Mathematical modelling؛ Drug delivery؛ Viscoelastic؛ Numerical simulations؛ Stability analysis | ||
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آمار تعداد مشاهده مقاله: 102 تعداد دریافت فایل اصل مقاله: 75 |
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