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پیشبینی بیماری آلزایمر با استفاده از الگوریتمهای انتخاب ویژگی محاسبات نرم و بر پایه rs-fMRI و sMRI | ||
مجله مهندسی برق دانشگاه تبریز | ||
مقاله 8، دوره 49، شماره 2 - شماره پیاپی 88، مرداد 1398، صفحه 551-563 اصل مقاله (1.4 M) | ||
نوع مقاله: علمی-پژوهشی | ||
نویسندگان | ||
سید هانی حجتی1؛ عطاالله ابراهیم زاده1؛ علی خزائی* 2؛ عباس باباجانی فرمی3 | ||
1دانشکده مهندسی برق و کامپیوتر - دانشگاه صنعتی نوشیروانی بابل | ||
2دانشکده مهندسی برق و کامپیوتر - دانشگاه بجنورد | ||
3دانشکده آناتومی و نوروبیولوژی- دانشگاه مرکز علوم بهداشت تنسی– ممفیس - آمریکا | ||
چکیده | ||
بیماری آلزایمر (AD)، یک بیماری پیشرفته و غیرقابلبرگشت است که اغلب در افراد مسن رخ میدهد و بهتدریج مناطق مغز را که مسئول حافظه، تفکر، یادگیری و رفتار هستند، از بین میبرد. در این مقاله پیشبینی AD بر اساس تصاویر rs-fMRI و sMRI بررسی میشود. در این مطالعه سه الگوریتم انتخاب ویژگی بر اساس روش محاسبات نرم ارائه شده، که طبقهبندی MCI-C از MCI-NC با آموزش و آزمایش الگوریتم SVM انجام میشود. این اولین مطالعهای است که از ادغام rs-fMRI و sMRI برای پیشبینی AD استفاده کرده است. نتایج حاصل از این مطالعه میتواند به مناطق شناخته شده مغز )عملکردی و ساختاری( که در بیماری آلزایمر دچار اختلال شدهاند، منجر شود. علاوه بر این، روش NBS بر روی تقسیمبندیهای عملکردی مغز، برای جداسازی MCI-C از MCI-NC و تشخیص زیر شبکههایی که دارای قابلیت تشخیصی برای پیشبینی AD هستند، به کار گرفته شده است. | ||
کلیدواژهها | ||
بیماری آلزایمر؛ پیشبینی؛ تئوری گراف؛ اطلاعات آماری مغز؛ تصویربرداری تشدید مغناطیسی؛ آنالیز مبتنی بر شبکه | ||
مراجع | ||
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