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بررسی تاثیر جنسیت بر علایم ناشی از بیماری بیشفعالی بر مبنای ارزیابی تغییرات تراکم ماده خاکستری مغز | ||
مجله مهندسی برق دانشگاه تبریز | ||
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 01 اردیبهشت 1403 اصل مقاله (574.62 K) | ||
نوع مقاله: علمی-پژوهشی | ||
شناسه دیجیتال (DOI): 10.22034/tjee.2024.59859.4790 | ||
نویسندگان | ||
مژده حدادپور1؛ مهدی سعادتمند* 2؛ فابریس والویس3 | ||
1دانشجوی دکترا، مهندسی پزشکی (دانشکده مهندسی)، دانشگاه فردوسی مشهد، مشهد، ایران | ||
2دانشیار، مرکز علوم و فناوریهای شناختی فردوسی & آزمایشگاه تصویربرداری پزشکی، گروه مهندسی برق، دانشکده مهندسی، دانشگاه فردوسی مشهد، مشهد، ایران | ||
3استاد و پزشک، دانشکده پزشکی، دانشگاه پیکاردی ژول ورن، امیان، فرانسه | ||
چکیده | ||
اختلال نقص توجه/بیشفعالی (ADHD) یکی از شایعترین اختلالات دوران کودکی است که عمدتاً با سه علامت اصلی شامل بیتوجهی، بیشفعالی و تکانشگری مشخص میشود. این علائم در دختران و پسران بهصورت متفاوتی بروز مییابند. در این مطالعه، رابطه بین اختلال ADHD و تراکم ماده خاکستری (GM) مغز با تمرکز بر تفاوتهای جنسیتی بررسی شده است. دادههای تصویربرداری ساختاری MRI از پایگاه داده ADHD-200 استخراج گردید که شامل ۱۶۴ پسر سالم، ۲۲۷ پسر مبتلا به ADHD، ۱۲۹ دختر سالم و ۶۷ دختر مبتلا به ADHD در بازه سنی ۷ تا ۱۴ سال میباشد. از روش مورفومتری مبتنی بر واکسل (VBM) برای مقایسه تراکم ماده خاکستری بین گروههای ADHD و کنترل در هر جنس استفاده شد. نتایج این پژوهش نشان میدهد که در پسران، نواحی شکنج خلفی کمربندی، پیشگوه، هیپوکامپ و تالاموس، و در دختران، ناحیه مخچه بهطور معناداری تحت تأثیر این اختلال قرار گرفتهاند. این نواحی در فرایندهای شناختی مانند یادگیری، حافظه، تنظیم هیجان و پردازش بینایی نقش دارند؛ از اینرو، پسران مبتلا به ADHD ممکن است در این عملکردها دچار اختلال شوند، در حالیکه دختران بیشتر با مشکلات توجه مواجهاند. | ||
کلیدواژهها | ||
اختلال نقصوجهی/بیشفعالی (ADHD)؛ مورفومتری مبتنی بر وکسلVBM))؛ تفاوتهای جنسیتی؛ تراکم ماده خاکستری؛ تصویربرداری ساختاری MRI؛ اختلالات عصبیرشدی | ||
مراجع | ||
[1] A. Bikic, J. F. Leckman, J. Lindschou, T. Ø. Christensen, and S. Dalsgaard, "Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial", Trials, vol. 16, pp. 1-13, 2015. [2] A. E. Vierhile, D. Palumbo, and H. Belden, "Diagnosis and treatment of attention deficit hyperactivity disorder", The Nurse Practitioner, vol. 42, no. 10, pp. 48-54, 2017. [3] I. W. Hwang, B. N. Kwon, H. J. Kim, S. H. Han, N. R. Lee, M. H. Lim, and et al., "Assessment of associations between mitochondrial DNA haplogroups and attention deficit and hyperactivity disorder in Korean children", Mitochondrion, vol. 47, pp. 174-178, 2019. [4] F. Mowlem, J. Agnew-Blais, E. Taylor, and P. Asherson, "Do different factors influence whether girls versus boys meet ADHD diagnostic criteria? Sex differences among children with high ADHD symptoms", Psychiatry research, vol. 272, pp. 765-773, 2019. [5] U. Klefsjö, A. K. Kantzer, C. Gillberg, and E. Billstedt, "The road to diagnosis and treatment in girls and boys with ADHD–gender differences in the diagnostic process", Nordic journal of psychiatry, vol. 75, no. 4, pp. 301-305, 2021. [6] A. S. Bell, "A critical review of ADHD diagnostic criteria: What to address in the DSM-V", Journal of Attention Disorders, vol. 15, no. 1, pp. 3-10, 2011. [7] C. Sridhar, S. Bhat, U. R. Acharya, H. Adeli, and G. M. Bairy, "Diagnosis of attention deficit hyperactivity disorder using imaging and signal processing techniques", Computers in Biology and Medicine, vol. 88, pp. 93-99, 2017. [8] فریما مقدم، پیوند قادریان، موسی شمسی، «تشخیص بیماری نقص توجه/بیشفعالی به کمک تحلیل ارتباطات نواحی مختلف مغزی و روش تابخوردگی زمانی پویا»، مجله مهندسی برق دانشگاه تبریز، صفحات 223-233 ، 1402. [9] سید هانی حجتی، عطااله ابراهیم زاده، علی خزائی، عباس باباجانی فرمی، «پیشبینی بیماری آلزایمر با استفاده از الگوریتمهای انتخاب ویژگیهای محاسبات نرم و برپایه rs-fMRI و sMRI»، مجله مهندسی برق دانشگاه تبریز، صفحات 551-563، 1398. [10] C. Scarpazza and M. Stefania De Simone, "Voxel-based morphometry: current perspectives", Neuroscience and Neuroeconomics, pp. 19-35, 2016. [11] V. Vilgis, L. Sun, J. Chen, T. J. Silk, and A. Vance, "Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type", Psychiatry Research: Neuroimaging, vol. 254, pp. 119-126, 2016. [12] B. Bonath, J. Tegelbeckers, M. Wilke, H.-H. Flechtner, and K. Krauel, "Regional gray matter volume differences between adolescents with ADHD and typically developing controls: further evidence for anterior cingulate involvement", Journal of attention disorders, vol. 22, no. 7, pp. 627-638, 2018. [13] U. P. Ramtekkar, A. M. Reiersen, A. A. Todorov, and R. D. Todd, "Sex and age differences in attention-deficit/hyperactivity disorder symptoms and diagnoses: implications for DSM-V and ICD-11", Journal of the American Academy of Child & Adolescent Psychiatry, vol. 49, no. 3, pp. 217-228. e3, 2010. [14] G. H. Gudjonsson, J. F. Sigurdsson, I. D. Sigfusdottir, and S. Young, "A national epidemiological study of offending and its relationship with ADHD symptoms and associated risk factors", Journal of attention disorders, vol. 18, no. 1, pp. 3-13, 2014. [15] L.-J. Wang, S.-Y. Lee, S.-S. Yuan, C.-J. Yang, K.-C. Yang, [16] O. Slobodin and M. Davidovitch, "Gender differences in objective and subjective measures of ADHD among clinic-referred children", Frontiers in human neuroscience, vol. 13, p. 441, 2019. [17] P. Quinn, 100 Questions & Answers About Attention Deficit Hyperactivity Disorder (ADHD) in Women and Girls. Jones & Bartlett Learning, 2010. [18] K. Bruchmüller, J. Margraf, and S. Schneider, "Is ADHD diagnosed in accord with diagnostic criteria? Overdiagnosis and influence of client gender on diagnosis", Journal of consulting and clinical psychology, vol. 80, no. 1, p. 128, 2012. [19] K. E. Seymour, X. Tang, D. Crocetti, S. H. Mostofsky, M. I. Miller, and K. S. Rosch", Anomalous subcortical morphology in boys, but not girls, with ADHD compared to typically developing controls and correlates with emotion dysregulation", Psychiatry Research: Neuroimaging, vol. 261, pp. 20-28, 2017. [20] A. M. H. Onnink, M. P. Zwiers, M. Hoogman, J. C. Mostert, C. C. Kan and J. Buitelaar et al., "Brain alterations in adult ADHD: effects of gender, treatment and comorbid depression", European Neuropsychopharmacology, vol. 24, no. 3, pp. 397-409, 2014. [21] K. S. Rosch, D. Crocetti, K. Hirabayashi, M. B. Denckla, S. H. Mostofsky, and E. M. Mahone, "Reduced subcortical volumes among preschool-age girls and boys with ADHD", Psychiatry Research: Neuroimaging, vol. 271, pp. 67-74, 2018. [22] L. Lu, Z. Lianqing, T. Shi, B. Xuan, C. Ying, H. Xinyu, and et al., "Characterization of cortical and subcortical abnormalities in drug-naive boys with attention-deficit/hyperactivity disorder", Journal of affective disorders, vol. 250, pp. 397-403, 2019. [23] A. Hutchinson, J. Mathias, and M. Banich, "Corpus callosum morphology in children and adolescents with attention deficit hyperactivity disorder: a meta-analytic review", Neuropsychology, vol. 22, no. 3, p. 341, 2008. [24] C. Gaser, R. Dahnke, P. M. Thompson, F. Kurth, E. Luders, and A. s. D. N. Initiative, "CAT–A computational anatomy toolbox for the analysis of structural MRI data", biorxiv, p. 2022.06. 11.495736, 2022. [25] J. Ashburner, G. Barnes, C. C. Chen, J. Daunizeau, G. Flandin, K. Friston, and et al., "SPM12 manual", Wellcome Trust Centre for Neuroimaging, London, UK, vol. 2464, no. 4, 2014. [26] F. Farokhian, I. Beheshti, D. Sone, and H. Matsuda, "Comparing CAT12 and VBM8 for detecting brain morphological abnormalities in temporal lobe epilepsy", . Frontiers in neurology, 8: p. 428, 2017. [27] S. Etemadi, M. Saadatmand-Tarzjan, M. Shamirzaei, and J. Khosravi, "An efficient 3D gradient-based algorithm for medical image registration using correlation-coefficient maximization", in 2014 4th International Conference on Computer and Knowledge Engineering (ICCKE), pp. 663-668: IEEE, 2014. [28] E. T. Rolls, C.-C. Huang, C.-P. Lin, J. Feng, and M. Joliot, "Automated anatomical labelling atlas 3", Neuroimage, vol. 206, p. 116189, 2020. [29] P. Bellec, C. Chu, F. Chouinard-Decorte, Y. Benhajali, D. S. Margulies, and R. C. Craddock", The neuro bureau ADHD-200 preprocessed repository", Neuroimage, vol. 144, pp. 275-286, 2017. [30] S. Carmona, O. Vilarroya, A. Bielsa, V. Trèmols, J.C. Soliva, M. Rovira, and et al., "Global and regional gray matter reductions in ADHD: a voxel-based morphometric study", Neuroscience letters, vol. 389, no. 2, pp. 88-93, 2005. [31] K. Nickel, L. T. v. Elst, J. Manko, J. Unterrainer, R. Rauh, C. Klein, D. Endres, and et al., "Inferior frontal gyrus volume loss distinguishes between autism and (comorbid) attention-deficit/hyperactivity disorder—a FreeSurfer analysis in children", Frontiers in psychiatry, vol. 9, p. 521, 2018. [32] T. Nakao, J. Radua, K. Rubia, and D. Mataix-Cols, "Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication", American Journal of Psychiatry, vol. 168, no. 11, pp. 1154-1163, 2011. [33] M. Haddadpour, F. Wallois, and M. Saadatmand, "Statistical analysis of brain volume changes in T1-weighted magnetic resonance images of attention deficit hyperactivity disorder (ADHD) based on voxel-based morphometry", in 2020 8th Iranian Joint Congress on Fuzzy and intelligent Systems (CFIS), pp. 93-98: IEEE, 2020. [34] O. Gonchigsuren, M. Harada, S. Hisaoka, K. Higashi, Y. Matsumoto, N. Sumida, and et al., "Brain abnormalities in children with attention-deficit/hyperactivity disorder assessed by multi-delay arterial spin labeling perfusion and voxel-based morphometry", Japanese Journal of Radiology, vol. 40, no. 6, pp. 568-577, 2022. [35] H. Y. Seok and D. H. Lee, "Magnetic resonance imaging of idiopathic herniation of the lingual gyrus: A case report", Investigative Magnetic Resonance Imaging, vol. 21, no. 3, pp. 195-198, 2017. [36] R. Leech and D. J. Sharp, "The role of the posterior cingulate cortex in cognition and disease", Brain, vol. 137, no. 1, pp. 12-32, 2014. [37] N. B. Dadario and M. E. Sughrue, "The functional role of the precuneus", Brain, vol. 146, no. 9, pp. 3598-3607, 2023. [38] Y. Wang , Q. Xu, S. Li, G. Li, C. Zuo, S. Liao, and et al., "Gender differences in anomalous subcortical morphology for children with ADHD", Neuroscience letters, vol. 665, pp. 176-181, 2018. [39] K. A. Kovács, "Episodic memories: how do the hippocampus and the entorhinal ring attractors cooperate to create them?," Frontiers in systems neuroscience, vol. 14, p. 559168, 2020. [40] J. Pearson, "The human imagination: the cognitive neuroscience of visual mental imagery," Nature reviews neuroscience, vol. 20, no. 10, pp. 624-634, 2019. [41] T. Bailey and A. Joyce, "The role of the thalamus in ADHD symptomatology and treatment," Applied Neuropsychology: Child, vol. 4, no. 2, pp. 89-96, 2015. [42] S. M. Sherman, "Thalamus," Scholarpedia, vol. 1, no. 9, p. 1583, 2006. [43] J. V. M. Gordana Sendić. (November 03, 2023). Thalamic nuclei. Available: https://www.kenhub.com/en/library/anatomy/thalamic-nuclei [44] C. Fu, S. Chen, A. Qian, R. Zhou, J. Zhou, J. Li, and et al., "Larger thalamus correlated with inattentive severity in the inattentive subtype of ADHD without comorbidity", Psychiatry Research, vol. 304, p. 114079, 2021. [45] I. Ivanov, R. Bansal, X. Hao, H. Zhu, C. Kellendonk, L. Miller, and et al., "Morphological abnormalities of the thalamus in youths with attention deficit hyperactivity disorder", American Journal of Psychiatry, vol. 167, no. 4, pp. 397-408, 2010. [46] M. J. Batty, L. Palaniyappanet, G. Scerif, M. J. Groom, E. B. Liddle, P. F. Liddle, and et al., "Morphological abnormalities in prefrontal surface area and thalamic volume in attention deficit/hyperactivity disorder", Psychiatry Research: Neuroimaging, vol. 233, no. 2, pp. 225-232, 2015. [47] H. Li, Q. Yuan, Y.-J. Luo, and W. Tao, "A new perspective for understanding the contributions of the cerebellum to reading: the cerebro-cerebellar mapping hypothesis", Neuropsychologia, vol. 170, p. 108231, 2022. [48] M. M. Bruchhage, M.-P. Bucci, and E. B. Becker, "Cerebellar involvement in autism and ADHD", Handbook of clinical neurology, vol. 155, pp. 61-72, 2018. [49] O. Baumann, R. Borra, J. M. Bower, K. E. Cullen, C. Habas, R. B. Ivry, and et al., "Consensus paper: the role of the cerebellum in perceptual processes", The Cerebellum, vol. 14, pp. 197-220, 2015. [50] C. Clinic. ADHD in Women: Symptoms, Diagnosis & Treatment. Available: https://my.clevelandclinic.org/health/diseases/24741-adhd-in-women. [51] V. U. Vildalen, E. J. Brevik, J. Haavik, and A. J. Lundervold, "Females with ADHD report more severe symptoms than males on the adult ADHD self-report scale", Journal of attention disorders, vol. 23, no. 9, pp. 959-967, 2019. [52] K. A. Coffman, R. P. Dum, and P. L. Strick, "Cerebellar vermis is a target of projections from the motor areas in the cerebral cortex", Proceedings of the National Academy of Sciences, vol. 108, no. 38, pp. 16068-16073, 2011. [53] A. Wyciszkiewicz, M. A. Pawlak, and K. Krawiec, "Cerebellar volume in children with attention-deficit hyperactivity disorder (ADHD) replication study", Journal of child neurology, vol. 32, no. 2, pp. 215-221, 2017. [54] L. Fernandez, A. Burmester, J. D. Duque, T. J. Silk, C. E. Hyde, M. Kirkovski, and et al.,"Examination of cerebellar grey-matter volume in children with neurodevelopmental disorders: a coordinated analysis using the ACAPULCO algorithm", The Cerebellum, vol. 22, no. 6, pp. 1243-1249, 2023. [55] L. C. Rice, R. N. Rochowiak, M. R. Plotkin, K. S. Rosch, S. H. Mostofsky, and D. Crocetti, "Sex Differences and Behavioral Associations with Typically Developing Pediatric Regional Cerebellar Gray Matter Volume", The Cerebellum, pp. 1-12, 2023. [56] E. M. Mahone, M. E. Ranta, D. Crocetti, J. O'Brien, W. E. Kaufmann, M. B. Denckla, and S. H. Mostofsky, "Comprehensive examination of frontal regions in boys and girls with attention-deficit/hyperactivity disorder", Journal of the International Neuropsychological Society, 17(6): p. 1047-1057, 2011. [57] T. Villemonteix, S. A. De Brito, H. Slama, M. Kavec, D. Balériaux, T. Metens, and et al., "Grey matter volume differences associated with gender in children with attention-deficit/hyperactivity disorder: a voxel-based morphometry study", Developmental cognitive neuroscience, 32-37, 2015. [58] L. G. A. Montes, J. Ricardo-Garcell, L. De La Torre, H. P. Alcántara, R. B. Martínez García, D. Ávila Acosta, and A. Fernández Bouzas, "Cerebellar gray matter density in females with ADHD combined type: a cross-sectional voxel-based morphometry study. Journal of attention disorders", 15(5): p. 368-381, 2011. [59] E. D. Gennatas, J. Wren-Jarvis, R. Powers, M. C. Lazerwitz, I. Bourla, L. T. Cai, and et al., " Gray matter correlates of attention-deficit hyperactivity disorder in boys versus girls with sensory processing dysfunction", Imaging Neuroscience, 2, 1-14, 2024. [60] M. Øie, K. T. Hovik, P. N. Andersen, N. O. Czajkowski, and E. W. Skogli, "Gender differences in the relationship between changes in ADHD symptoms, executive functions, and self-and parent-report depression symptoms in boys and girls with ADHD: A 2-year follow-up study", Journal of attention disorders, 22(5): p. 446-459, 2018. [61] X. Luo, W. Fang, X. Guo, Y. Chen, Y. Tan, L. Wang, and et al., "Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain", Translational Psychiatry, 12(1): p. 225, 2022. | ||
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