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Intraspecific variation of major alkaloids in Afghanistan opium poppy (Papaver somniferum L.) | ||
| Journal of Plant Physiology and Breeding | ||
| مقاله 1، دوره 14، شماره 1، شهریور 2024، صفحه 1-16 اصل مقاله (915.13 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22034/jppb.2024.59386.1324 | ||
| نویسندگان | ||
| Sayed Zia Rasekh1؛ Ghasem Karimzadeh* 2؛ Alireza Ghassempour3 | ||
| 1Department of Plant Genetics and Breeding, College of Agriculture, Tarbiat Modares University, Tehran, Iran | ||
| 2Department of Plant Genetics and Breeding, College of Agriculture, Tarbiat Modares University, Tehran, P. O. Box 14115-336, Iran | ||
| 3Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran | ||
| چکیده | ||
| Objective: Opium poppy (Papaver somniferum L.) is an important source of physiologically active medicinal alkaloids. It is one of the world’s best medicinal plants and the only commercial source for narcotic analgesics, morphine, codeine, the vasodilator papaverine, the cough suppressant, and the powerful anticancer drug noscapine. The current study aimed to examine the content of major alkaloids in the capsules of seven populations of poppies, collected from Balkh Province, Afghanistan. Methods: Three locations (replications) were considered for each population. In each location, 15 plants with the uniform main capsules were randomly selected. A 1.5 to 2 g of capsule powder was obtained from each population/replication. Such amounts collected from three locations were then mixed to assess the major alkaloids between populations, 200 mg of which was used for extraction. Major alkaloids (morphine, codeine, thebaine, noscapine, and papaverine) were measured, using the HPLC method. Results: The results indicated that the highest amount of noscapine (1398.4 µg/g DW), papaverine (802.6 µg/g DW), and thebaine (1129.2 µg/g DW) were detected in the P1 population, which appeared to be the most valuable medicinal-industrial population. For morphine and codeine, P6 (2947.7 µg/g DW) and P7 (5638.3 µg/g DW), respectively, had the highest amounts of these substances. Pharmacologically, the P4 population having the lowest morphine (narcotic drug) and the highest thebaine (non-narcotic drug) is prescribable for the medication of addicts. Monoploid genome size (2Cx DNA) was positively and significantly related to noscapine, papaverine, and codeine, indicating that a higher genome size population produced more of these alkaloids. The UPGMA phenogram constructed based on 10 variables showed four distinct cluster groups of the studied populations. Conclusion: The P1 population stood out for its medicinal and industrial value due to its high contents of noscapine, papaverine, and thebaine. Conversely, The P4 population, while containing the lowest level of morphine (a narcotic drug), also had a relatively high amount of thebaine (a non-narcotic precursor to other alkaloids). These dual-compounds metabolites make it a potentially useful population to treat drug-affected patients. | ||
| کلیدواژهها | ||
| Afghanistan؛ HPLC؛ Major alkaloids؛ Papaver somniferum | ||
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Abedini D, Monfared SR, Abbasi A. 2018. The effects of promoter variations of the N-Methylcanadine 1-Hydroxylase (CYP82Y1) gene on the noscapine production in opium poppy. Sci Rep. 8: 4973. doi.org/10.1038/s41598-018-23351-0
Abdollahi M, Sefidkon F, Calagari M, Mousavi A, Mahomoodally MF. 2020. Impact of four hemp (Cannabis sativa L.) varieties and stage of plant growth on yield and composition of essential oils. Ind Crops Prod. 155: 112793. doi.org/10.1016/j.indcrop.2020.112793
Acevska J, Stefkov G, Nakov N, Petkovska R, Ugrinova L, Kulevanova S, Dimitrovska A. 2014. Chemometric approach for the development, optimization and validation of hilic methods used for the determination of alkaloids from poppy straw. Maced J Chem Chem Eng. 33(1): 73-83. doi.org/10.20450/mjcce.2014.6
Akhgari A, Laakso I, Maaheimo H, Choi, YH, Seppänen-Laakso T, Oksman-Caldentey KM, Rischer H. 2019. Methyljasmonate elicitation increases terpenoid indole alkaloid accumulation in Rhazya stricta hairy root cultures. Plants 8(12): 534. doi.org/10.3390/plants8120534
Bagheri M, Taheri M, Farhadpour M, Rezadoost H, Ghassempour A, Aboul-Enein HY. 2017. Evaluation of hydrophilic interaction liquid chromatography stationary phases for analysis of opium alkaloids. J. Chromatogr A. 1511: 77-84. doi.org/10.1016/j.chroma.2017.06.072
Battersby AR, Francis RJ, Hirst M, Southgate R, Staunton J. 1967. Stereochemical studies concerning the biosynthesis of narcotine, protopine, and chelidonine. Chem Comm. 12: 602-604.
Carlin MG, Dean JR, Ames JM. 2020. Opium alkaloids in harvested and thermally processed poppy seeds. Front Chem. 8: 737. doi.org/10.3389/fchem.2020.00737
Cho HY, Lee-Parsons CW, Yoon SYH, Rhee HS, Park JM. 2007. Enhanced benzophenanthridine alkaloid production and protein expression with combined elicitor in Eschscholtzia californica suspension cultures. Biotechnol Lett. 29: 2001-2005. doi.org/10.1007/s10529-007-9469-4
Dittbrenner A, Mock HP, Börner A, Lohwasser U. 2012. Variability of alkaloid content in Papaver somniferum L. J Appl Bot Food Qual. 82(2): 103-107.
Filipiak-Szok A, Kurzawa M, Szłyk E. 2018. Simultaneous determination of isoquinoline alkaloids in medicinal asiatic plants by ultrasound-assisted extraction and high-performance liquid chromatography-mass spectrometry with principal component analysis. Anal Lett. 51(16): 2575-2585. doi.org/10.1080/00032719.2018.1439050
Ganorkar SB, Shirkhedkar AA. 2017. Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications, and future prospects. Rev Anal Chem. 36(3): 20160025. doi.org/10.1515/revac-2016-0025
Garland‐Campbell K. 2018. Errors in statistical decision making. In: Glaz B, Yeater KM (eds.). Applied Statistics in Agricultural, Biological, and Environmental Sciences. Chapter 1, pp.1-18. American Society of Agronomy, Inc. Soil Science Society of America, Inc. Crop Science Society of America, Inc., USA. doi.org/10.2134/appliedstatistics.2015.0083
Gümüşçü A, Arslan N, Sarıhan EO. 2007. Evaluation of selected poppy (Papaver somniferum L.) lines by their morphine and other alkaloids contents. Eur Food Res Technol. 226: 1213-1220. doi.org/10.1007/s00217-007-0739-0
Hagel JM, Facchini PJ. 2010. Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. Nat Chem Biol. 6(4): 273-275. doi.org/10.1038/nchembio.317
Han X, Lamshöft M, Grobe N, Ren X, Fist AJ, Kutchan TM, Zenk MH. 2010. The biosynthesis of papaverine proceeds via (S)-reticuline. Phytochemistry 71(11-12): 1305-1312. doi.org/10.1016/j.phytochem.2010.04.022
Holková I, Bezáková L, Bilka F, Balažová A, Vanko M, Blanáriková V. 2010. Involvement of lipoxygenase in elicitor-stimulated sanguinarine accumulation in Papaver somniferum suspension cultures. Plant Physiol Biochem. 48: 887-892. doi.org/10.1016/j.plaphy.2010.08.004
Jesus A, Bonhomme V, Evin A, Ivorra S, Soteras R, Salavert A, Bouby L. 2021. A morphometric approach to track opium poppy domestication. Sci Rep. 11(1): 9778. doi.org/10.1038/s41598-021-88964-4
Kara N, Baydar H. 2018. Examining of relationships among traits using correlation, path and principal components analysis methods in Turkish opium poppy (Papaver somniferum L.) cultivars. J Agr Sci -Tarim Bili. 24: 286-295. doi.org/10.15832/ankutbd.446462
Kara N, Baydar H. 2021. The alkaloid content of poppy (Papaver somniferum L.) varieties in Turkey by their correlation and path coefficient relationships. Int J Agric Environ Food Sci. 5: 450-455. doi.org/10.31015/jaefs.2021.4.3
Kumar R, Sharma S, Sharma S, Kumari A, Kumar D, Nadda G, Kumar N. 2016. Chemical composition, cytotoxicity and insecticidal activities of Acorus calamus accessions from the western Himalayas. Ind Crops Prod. 94: 520-527. doi.org/10.1016/j.indcrop.2016.09.024
Labanca F, Ovesnà J, Milella L. 2018. Papaver somniferum L. taxonomy, uses and new insight in poppy alkaloid pathways. Phytochem Rev. 17: 853-871. doi.org/10.1007/s11101-018-9563-3
Liang SY, Shi F, Zhao YG, Wang HW. 2022. Determination of local anesthetic drugs in human plasma using magnetic solid-phase extraction coupled with high-performance liquid chromatography. Molecules 27(17): 5509. doi.org/10.3390/molecules27175509
Madani H, Hosseini B, Karimzadeh G, Rahimi A. 2019. Enhanced thebaine and noscapine production and modulated gene expression of tyrosine/dopa decarboxylase and salutaridinol 7-O-acetyltransferase genes in induced autotetraploid seedlings of Papaver bracteatum Lindl. Acta Physiol Plant. 41: 194. doi.org/10.1007/s11738-019-2984-9
Miller, JAC, Henning L, Heazlewood VL, Larkin PJ, Chitty J, Allen R, Brown PH, Gerlach WL, Fist AJ. 2005. Pollination biology of oilseed poppy, Papaver somniferum L. Aust J Agric Res. 56(5): 483-490. doi.org/10.1071/AR04234
Mishra BK, Pathak S, Sharma A, Trivedi PK, Shukla S. 2010. Modulated gene expression in newly synthesized auto-tetraploid of Papaver somniferum L. S Afr J Bot. 76: 447-452. doi.org/10.1016/j.sajb.2010.02.090
Omidbaigi R. 2005. Production and Processing of Medicinal Plants, Vol. 2. Astan Quds Razavi Publications (Behnashr Co.), Mashhad, Iran (In Persian).
Onoyovwe A, Hagel JM, Chen X, Khan MF, Schriemer DC, Facchini PJ. 2013. Morphine biosynthesis in opium poppy involves two cell types: sieve elements and laticifers. The Plant Cell 25(10): 4110-4122. doi.org/10.1105/tpc.113.115113
Ozber N, Facchini PJ. 2022. Phloem-specific localization of benzylisoquinoline alkaloid metabolism in opium poppy. J Plant Physiol. 271: 153641. doi.org/10.1016/j.jplph.2022.153641
Pothier J, Galand N. 2005. Automated multiple development thin-layer chromatography for separation of opiate alkaloids and derivatives. J Chromatogr A.1080: 186-191. doi.org/10.1016/j.chroma.2005.05.023
Rasekh SZ, Karimzadeh G. 2023. Chromosomal and genome size variations in opium poppy (Papaver somniferum L.) from Afghanistan. Caryologia. 76(4): 15-22. doi.org/10.36253/caryologia-1955
Sankar R, Snehalaltha KS, Firdose ST. 2019. Applications of HPLC in pharmaceutical analysis. Int J Pharm Sci Rev Res. 59: 117-124.
Sankar R, Madhuri B, Lakshmi AN, Pooja A, Sai MB. 2020. Selected HPLC applications-quick separation guide: A Review. Int J Pharm Sci Rev Res. 60: 13-20.
Santos VAD, Coppede JDS, Dias NB, Pereira AMS, Palma MS, Furlan M. 2022. Proteome profiling of methyl jasmonate elicitation of Maytenus ilicifolia in vitro roots reveals insights into sesquiterpene pyridine alkaloids. Plant Cell Tissue Organ Cult. 151: 551-563. doi.org/10.1007/s11240-022-02371-d
Sharopov F, Valiev A, Gulmurodov I, Sobeh M, Satyal P, Wink M. 2018. Alkaloid content, antioxidant, and cytotoxic activities of various parts of Papaver somniferum. Pharm Chem J. 52: 459-463. doi.org/10.1007/s11094-018-1839-9
Singh M, Chaturvedi N, Shasany AK, Shukla AK. 2014. Impact of promising genotypes of Papaver somniferum L. developed for beneficial uses. Acta Hortic. 1036: 29-42. doi:10.17660/ActaHortic.2014.1036.3
Singh SK, Gupta S, Ahmad N, Shukla AK, Shasany AK, Lal RK, Gupta MM, Dhawan OP. 2017. Variability and heritability studies in floral homeotic mutants of Papaver somniferum L. Ind Crops Prod. 95: 276-285. doi.org/10.1016/j.indcrop.2016.10.032
Solanki G, Dodiya NS, Kunwar R, Bisen P, Kumar R, Singh JS. 2017. Character association and path coefficient analysis for seed yield and latex yield in opium poppy (Papaver somniferum L.). Int J Curr Microbiol Appl dci. 6: 1116-1123. doi.org/10.20546/ijcmas.2017.602.138
Tajabadi F, Khalighi-Sigaroodi F, Nahooji MG, Ghiaci-Yekta M, Ghasemi SV. 2022. Selective and simple determination of isoquinoline alkaloids in Papaver species by ion mobility spectrometry. Iran J Pharm Res. 21: 1-9. doi.org/10.5812/ijpr-127037
Tarkesh Esfahani S, Karimzadeh G, Naghavi MR, Vrieling K. 2021. Altered gene expression and root thebaine production in polyploidized and methyl jasmonate-elicited Papaver bracteatum Lindl. Plant Physiol. Biochem. 158: 334-341. doi.org/10.1016/j.plaphy.2020.11.021
Unterlinner B, Lenz R, Kutchan TM. 1999. Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum. Plant J. 18: 465-475. doi.org/10.1046/j.1365-313X.1999.00470.x
Vadhel A, Bashir S, Mir AH, Girdhar M, Kumar D, Kumar A, Mohan A. 2023. Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence. Open Biol. 13(5): 220355. doi.org/10.1098/rsob.220355 | ||
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